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Percocet 10.325 works by altering the way the brain and nervous system respond to pain, while acetaminophen enhances the pain-relieving effects of oxycodone. Due to its opioid content, Percocet has a high potential for misuse, addiction, and overdose, particularly if taken in higher doses or for extended periods. Common side effects include drowsiness, dizziness, nausea, constipation, and respiratory depression,